MolNFT v1 · #43402 · protein + RNA

Solution structure of double-stranded RNA binding domain of S. cerevisiae RNase III (RNT1P) in complex with aagu tetraloop hairpin

2LBS · RNA (32-mer): “Solution structure of double-stranded RNA binding domain of S. cerevisiae RNase III (RNT1P) in complex with…”. Solution nmr, 1 pocket (best druggability 0.63). MolNFT v1 #43402 on GenesisL1: 3D structure, binding…

PDB: 2LBS
Type: protein + RNA
Length: 122 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA (32-mer); Ribonuclease 3
EC: 3.1.26.3
UniProt: Q02555
Pockets: 1 · best druggability 0.63

Structure

solution nmr · 2 distinct chains · 41% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA (32-mer)	rna	32	—	—
B	Ribonuclease 3 (EC 3.1.26.3)	protein	90	41% helix, 23% strand	Q02555

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	544	0.63	0.76	35	empty

Interfaces

1 interface between chains.

A–B · 716 Å² buried · 6 hydrogen bonds · protein-nucleic

Compared structures

2LBS · Solution structure of double-stranded RNA binding domain of S. cerevisiae RNase III… · the same entry in another collection · chain A against A, TM-score 1.00
Q02555 · AlphaFold monomer V2.0 prediction for ribonuclease 3 (Q02555) · a predicted model of the same protein · chain B against A, TM-score 0.76

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q02555
Elsewhere: RCSB PDB 2LBS · PDBe 2LBS · UniProt Q02555

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