MolNFT v1 · #43292 · protein
Gabarapl-1 NBR1-lir complex structure
2L8J · Gamma-aminobutyric acid receptor-associated protein-like 1: “Gabarapl-1 NBR1-lir complex structure”. Solution nmr, 3 pockets (best druggability 0.54). MolNFT v1 #43292 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2L8J
- Type
- protein
- Length
- 137 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gamma-aminobutyric acid receptor-associated protein-like 1; NBR1-lir peptide
- UniProt
- Q9H0R8, Q14596
- Pockets
- 3 · best druggability 0.54
Structure
solution nmr · 2 distinct chains · 27% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Gamma-aminobutyric acid receptor-associated protein-like 1 | protein | 119 | 31% helix, 22% strand | Q9H0R8 |
| B | NBR1-lir peptide | protein | 18 | 0% helix, 11% strand | Q14596 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 83 | 0.54 | 0.84 | 20 | empty |
| 2 | 212 | 0.51 | 0.76 | 29 | empty |
| 3 | 77 | 0.29 | 0.73 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 721 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 2L8J · GABARAPL-1 NBR1-LIR complex structure · the same entry in another collection · chain A against A, TM-score 1.00
- Q9H0R8 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor-associated… · a predicted model of the same protein · chain A against A, TM-score 0.83
- Q14596 · AlphaFold monomer V2.0 prediction for next to BRCA1 gene 1 protein (Q14596) · a predicted model of the same protein · chain B against A, TM-score 0.21
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H0R8
- Every structure of UniProt Q14596
- Elsewhere: RCSB PDB 2L8J · PDBe 2L8J · UniProt Q9H0R8 · UniProt Q14596
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