MolNFT v1 · #43130 · protein

Solution structure of tandem SH2 domain from SPT6

2L3T · Transcription elongation factor SPT6: “Solution structure of tandem SH2 domain from SPT6”. Solution nmr, 7 pockets (best druggability 0.66). MolNFT v1 #43130 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2L3T
Type: protein
Length: 199 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcription elongation factor SPT6
UniProt: P23615
Pockets: 7 · best druggability 0.66

Structure

solution nmr · 1 distinct chain · 31% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcription elongation factor SPT6	protein	199	31% helix, 28% strand	P23615

Pockets

7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	80	0.66	0.91	22	empty
2	54	0.62	0.92	14	empty
3	193	0.59	0.81	31	empty
4	192	0.56	0.80	26	empty
5	81	0.39	0.78	15	empty

Compared structures

2L3T · Solution structure of tandem SH2 domain from Spt6 · the same entry in another collection · chain A against A, TM-score 1.00
P23615 · AlphaFold monomer V2.0 prediction for transcription elongation factor SPT6 (P23615) · a predicted model of the same protein · chain A against A, TM-score 0.85

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P23615
Elsewhere: RCSB PDB 2L3T · PDBe 2L3T · UniProt P23615

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