MolNFT v1 · #43129 · protein

Structure of the autoinhibited crk

2L3S · Autoinhibited crk protein: “Structure of the autoinhibited crk”. Solution nmr, 2 pockets (best druggability 0.40). MolNFT v1 #43129 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2L3S
Type: protein
Length: 163 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Autoinhibited crk protein
UniProt: Q04929
Pockets: 2 · best druggability 0.40

Structure

solution nmr · 1 distinct chain · 4% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Autoinhibited crk protein	protein	163	4% helix, 19% strand	Q04929

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	107	0.40	0.76	22	empty
2	62	0.29	0.74	14	empty

Compared structures

2L3S · Structure of the autoinhibited Crk · the same entry in another collection · chain A against A, TM-score 1.00
Q04929 · AlphaFold monomer V2.0 prediction for adapter molecule crk (Q04929) · a predicted model of the same protein · chain A against A, TM-score 0.40

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q04929
Elsewhere: RCSB PDB 2L3S · PDBe 2L3S · UniProt Q04929

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