MolNFT v1 · #43114 · protein + RNA

Solution structure of ADAR2 DSRBM1 bound to lsl RNA

2L3C · Double-stranded RNA-specific editase 1: “Solution structure of ADAR2 DSRBM1 bound to lsl RNA”. Solution nmr, 2 pockets (best druggability 0.55). MolNFT v1 #43114 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2L3C
Type: protein + RNA
Length: 108 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Double-stranded RNA-specific editase 1; RNA (34-mer)
EC: 3.5.-.-
UniProt: P51400
Pockets: 2 · best druggability 0.55

Structure

solution nmr · 2 distinct chains · 36% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Double-stranded RNA-specific editase 1 (EC 3.5.-.-)	protein	74	36% helix, 32% strand	P51400
B	RNA (34-mer)	rna	34	—	—

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	464	0.55	0.73	25	empty
2	118	0.51	0.81	18	empty

Interfaces

1 interface between chains.

A–B · 706 Å² buried · 11 hydrogen bonds · protein-nucleic

Compared structures

2L3C · Solution structure of ADAR2 dsRBM1 bound to LSL RNA · the same entry in another collection · chain A against A, TM-score 1.00
P51400 · AlphaFold monomer V2.0 prediction for double-stranded RNA-specific editase 1 (P51400) · a predicted model of the same protein · chain A against A, TM-score 0.77

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P51400
Elsewhere: RCSB PDB 2L3C · PDBe 2L3C · UniProt P51400

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