GL1X · GenesisL1 explorer

MolNFT v1 · #43049 · protein + DNA

Rdc refined solution structure of the thap zinc finger of THAP1 in complex with its 16BP RRM1 DNA target

2L1G · Thap domain-containing protein 1: “Rdc refined solution structure of the thap zinc finger of THAP1 in complex with its 16BP RRM1 DNA target”. Solution nmr, 1 ligand (ZN). MolNFT v1 #43049 on GenesisL1: 3D structure, binding sites…

PDB
2L1G
Type
protein + DNA
Length
119 residues
Chains
3
Method
solution nmr
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Thap domain-containing protein 1; DNA (5'-D(*GP*CP*TP*TP*GP*TP*GP*TP*GP*GP*GP*CP*AP*GP*CP*…
UniProt
Q9NVV9
Ligands
ZN

Structure

solution nmr · 3 distinct chains · 18% helix, 7% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AThap domain-containing protein 1protein8718% helix, 7% strandQ9NVV9
BDNA (5'-D(*GP*CP*TP*TP*GP*TP*GP*TP*GP*GP*GP*CP*AP*GP*CP*G)- 3')dna16——
CDNA (5'- D(P*CP*GP*CP*TP*GP*CP*CP*CP*AP*CP*AP*CP*AP*AP*GP*C)-3')dna16——

Ligands and binding sites

  • ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

3 interfaces between chains.

  • B–C · 787 Ų buried · 82 hydrogen bonds · nucleic-nucleic
  • A–B · 611 Ų buried · 13 hydrogen bonds · protein-nucleic
  • A–C · 579 Ų buried · 17 hydrogen bonds · protein-nucleic

Compared structures

  • 2L1G · RDC refined solution structure of the THAP zinc finger of THAP1 in complex with its 16bp… · the same entry in another collection · chain A against A, TM-score 1.00
  • Q9NVV9 · AlphaFold monomer V2.0 prediction for thap domain-containing protein 1 (Q9NVV9) · a predicted model of the same protein · chain A against A, TM-score 0.67

Analyse

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.