MolNFT v1 · #42994 · protein

Daxx helical bundle (dhb) domain / RASSF1C complex

2KZU · Death-associated protein 6: “Daxx helical bundle (dhb) domain / RASSF1C complex”. Solution nmr, 1 pocket (best druggability 0.37). MolNFT v1 #42994 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2KZU
Type: protein
Length: 112 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Death-associated protein 6; RAS association (RALGDS/AF-6) domain family 1
UniProt: Q4VX54, Q5TZT2
Pockets: 1 · best druggability 0.37

Structure

solution nmr · 2 distinct chains · 62% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Death-associated protein 6	protein	94	69% helix, 0% strand	Q4VX54
B	RAS association (RALGDS/AF-6) domain family 1	protein	18	22% helix, 0% strand	Q5TZT2

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	87	0.37	0.76	19	empty

Interfaces

1 interface between chains.

A–B · 611 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

2KZU · DAXX helical bundle (DHB) domain / Rassf1C complex · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q4VX54
Every structure of UniProt Q5TZT2
Elsewhere: RCSB PDB 2KZU · PDBe 2KZU · UniProt Q4VX54 · UniProt Q5TZT2

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