MolNFT v1 · #42948 · protein

Solution structure of the voltage-sensing domain of kvap

2KYH · Voltage-gated potassium channel: “Solution structure of the voltage-sensing domain of kvap”. Solution nmr, 3 pockets (best druggability 0.55). MolNFT v1 #42948 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2KYH
Type: protein
Length: 147 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Voltage-gated potassium channel
UniProt: Q9YDF8
Pockets: 3 · best druggability 0.55

Structure

solution nmr · 1 distinct chain · 81% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Voltage-gated potassium channel	protein	147	81% helix, 0% strand	Q9YDF8

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	110	0.55	0.84	25	empty
2	209	0.50	0.76	25	empty
3	73	0.34	0.76	15	empty

Compared structures

2KYH · Solution structure of the voltage-sensing domain of KvAP · the same entry in another collection · chain A against A, TM-score 1.00
Q9YDF8 · AlphaFold monomer V2.0 prediction for voltage-gated potassium channel (Q9YDF8) · a predicted model of the same protein · chain A against A, TM-score 0.70

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9YDF8
Elsewhere: RCSB PDB 2KYH · PDBe 2KYH · UniProt Q9YDF8

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