MolNFT v1 · #42882 · DNA + RNA
Solution structure of a fully modified 2'-F/2'-ome siRNA construct
2KWG · 5'-R(*(GF2)P*(OMG)P*(GF2)P*(OMU)P*(AF2)P*(A2M)P*(AF2)…: “Solution structure of a fully modified 2'-F/2'-ome siRNA construct”. Solution nmr. MolNFT v1 #42882 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2KWG
- Type
- DNA + RNA
- Length
- 42 nucleotides
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5'-R(*(GF2)P*(OMG)P*(GF2)P*(OMU)P*(AF2)P*(A2M)P*(AF2)…
Structure
solution nmr · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 5'-R(*(GF2)P*(OMG)P*(GF2)P*(OMU)P*(AF2)P*(A2M)P*(AF2) P*(OMU)P*(AF2)P*(OMC)P*(AF2)P*(OMU)P*(UFT)P*(OMC)P*(UFT)P*(OMU) P*(CFZ)P*(A2M)P*(UFT)P*(OMU)P*(UFT))-3' | dna | 21 | — | — |
| B | 5'-R(P*(A2M)P*(UFT)P*(OMG)P*(AF2)P*(A2M)P*(GF2)P*(A2M) P*(AF2)P*(OMU)P*(GF2)P*(OMU)P*(AF2)P*(OMU)P*(UFT)P*(OMU)P*(AF2) P*(OMC)P*(CFZ)P*(OMC)P*(UFT)P*(OMU))-3' | rna | 21 | — | — |
Interfaces
1 interface between chains.
- A–B · 988 Ų buried · 72 hydrogen bonds · nucleic-nucleic
Modifications
Observed in the structure: 42 modified (nucleotide modification).
Compared structures
- 2KWG · Solution structure of a fully modified 2'-F/2'-OMe siRNA construct · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2KWG · PDBe 2KWG
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