MolNFT v1 · #42873 · protein
Solution NMR structure of cyclin-dependent kinase 2-associated protein 1 (CDK2-associated protein 1; oral cancer suppressor deleted in oral cancer 1, doc-1) from H.SAPIENS, northeast structural genomics consortium target target HR3057H
2KW6: “Solution NMR structure of cyclin-dependent kinase 2-associated protein 1 (CDK2-associated protein 1; oral…”. Solution nmr, 2 pockets (best druggability 0.32). MolNFT v1 #42873 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 2KW6
- Type
- protein
- Length
- 130 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cyclin-dependent kinase 2-associated protein 1
- UniProt
- O14519
- Pockets
- 2 · best druggability 0.32
Structure
solution nmr · 1 distinct chain · 65% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Cyclin-dependent kinase 2-associated protein 1 | protein | 65 | 65% helix, 0% strand | O14519 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 69 | 0.32 | 0.75 | 12 | empty |
| 2 | 58 | 0.30 | 0.75 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1526 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 2KW6 · Solution NMR Structure of Cyclin-dependent kinase 2-associated protein 1 (CDK2-associated… · the same entry in another collection · chain A against A, TM-score 1.00
- O14519 · AlphaFold monomer V2.0 prediction for cyclin-dependent kinase 2-associated protein 1… · a predicted model of the same protein · chain A against A, TM-score 0.76
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14519
- Elsewhere: RCSB PDB 2KW6 · PDBe 2KW6 · UniProt O14519
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