MolNFT v1 · #42195 · protein

Solution structure of amino-terminal domain of DBP5P

2KBE · ATP-dependent RNA helicase DBP5: “Solution structure of amino-terminal domain of DBP5P”. Solution nmr, 3 pockets (best druggability 0.46). MolNFT v1 #42195 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2KBE
Type: protein
Length: 226 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ATP-dependent RNA helicase DBP5
EC: 3.6.1.-
UniProt: P20449
Pockets: 3 · best druggability 0.46

Structure

solution nmr · 1 distinct chain · 39% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ATP-dependent RNA helicase DBP5 (EC 3.6.1.-)	protein	226	39% helix, 12% strand	P20449

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	124	0.46	0.77	19	empty
2	53	0.40	0.82	15	empty
3	74	0.38	0.78	15	empty

Compared structures

2KBE · solution structure of amino-terminal domain of Dbp5p · the same entry in another collection · chain A against A, TM-score 1.00
P20449 · AlphaFold monomer V2.0 prediction for ATP-dependent RNA helicase DBP5 (P20449) · a predicted model of the same protein · chain A against A, TM-score 0.71

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P20449
Elsewhere: RCSB PDB 2KBE · PDBe 2KBE · UniProt P20449

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