MolNFT v1 · #42187 · protein

Solution NMR structure of eosinophil cationic PROTEIN/RNASE 3

2KB5: “Solution NMR structure of eosinophil cationic PROTEIN/RNASE 3”. Solution nmr, 1 pocket (best druggability 0.39). MolNFT v1 #42187 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2KB5
Type: protein
Length: 133 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Eosinophil cationic protein
EC: 3.1.27.-
UniProt: P12724
Pockets: 1 · best druggability 0.39

Structure

solution nmr · 1 distinct chain · 17% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Eosinophil cationic protein (EC 3.1.27.-)	protein	133	17% helix, 27% strand	P12724

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	97	0.39	0.76	15	empty

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

2KB5 · Solution NMR Structure of Eosinophil Cationic Protein/RNase 3 · the same entry in another collection · chain A against A, TM-score 1.00
P12724 · AlphaFold monomer V2.0 prediction for eosinophil cationic protein (P12724) · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P12724
Elsewhere: RCSB PDB 2KB5 · PDBe 2KB5 · UniProt P12724

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