MolNFT v1 · #42116 · protein

Solution structure of oxidised ERP18

2K8V · Thioredoxin domain-containing protein 12: “Solution structure of oxidised ERP18”. Solution nmr, 2 pockets (best druggability 0.37). MolNFT v1 #42116 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2K8V
Type: protein
Length: 157 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Thioredoxin domain-containing protein 12
EC: 1.8.4.2
UniProt: O95881
Pockets: 2 · best druggability 0.37

Structure

solution nmr · 1 distinct chain · 29% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Thioredoxin domain-containing protein 12 (EC 1.8.4.2)	protein	157	29% helix, 10% strand	O95881

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	109	0.37	0.74	19	empty
2	64	0.32	0.75	14	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

2K8V · Solution structure of Oxidised ERp18 · the same entry in another collection · chain A against A, TM-score 1.00
O95881 · AlphaFold monomer V2.0 prediction for thioredoxin domain-containing protein 12 (O95881) · a predicted model of the same protein · chain A against A, TM-score 0.68

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O95881
Elsewhere: RCSB PDB 2K8V · PDBe 2K8V · UniProt O95881

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