MolNFT v1 · #42068 · protein
Ensemble structures of the binary complex between the SH3 and SH2 domain of interleukin-2 tyrosine kinase.
2K7A · SH3 domain of tyrosine-protein kinase ITK/TSK: “Ensemble structures of the binary complex between the SH3 and SH2 domain of interleukin-2 tyrosine kinase.”. Solution nmr, 1 pocket (best druggability 0.29). MolNFT v1 #42068 on…
- PDB
- 2K7A
- Type
- protein
- Length
- 171 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SH3 domain of tyrosine-protein kinase ITK/TSK; SH2 domain of tyrosine-protein kinase…
- EC
- 2.7.10.2
- UniProt
- Q03526
- Pockets
- 1 · best druggability 0.29
Structure
solution nmr · 2 distinct chains · 12% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SH3 domain of tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) | protein | 63 | 0% helix, 16% strand | Q03526 |
| B | SH2 domain of tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) | protein | 108 | 19% helix, 17% strand | Q03526 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 59 | 0.29 | 0.74 | 11 | empty |
Interfaces
1 interface between chains.
- A–B · 781 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 2K7A · Ensemble Structures of the binary complex between the SH3 and SH2 domain of interleukin-2… · the same entry in another collection · chain A against A, TM-score 1.00
- Q03526 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase ITK/TSK (Q03526) · a predicted model of the same protein · chain B against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q03526
- Elsewhere: RCSB PDB 2K7A · PDBe 2K7A · UniProt Q03526
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