MolNFT v1 · #42067 · protein
Solution structure of the binary complex between the SH3 and SH2 domain of interleukin-2 tyrosine kinase
2K79 · SH3 domain of tyrosine-protein kinase ITK/TSK: “Solution structure of the binary complex between the SH3 and SH2 domain of interleukin-2 tyrosine kinase”. Solution nmr. MolNFT v1 #42067 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2K79
- Type
- protein
- Length
- 171 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SH3 domain of tyrosine-protein kinase ITK/TSK; SH2 domain of tyrosine-protein kinase…
- EC
- 2.7.10.2
- UniProt
- Q03526
Structure
solution nmr · 2 distinct chains · 13% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SH3 domain of tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) | protein | 63 | 0% helix, 25% strand | Q03526 |
| B | SH2 domain of tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) | protein | 108 | 20% helix, 22% strand | Q03526 |
Interfaces
1 interface between chains.
- A–B · 797 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 2K79 · Solution Structure of the binary complex between the SH3 and SH2 domain of interleukin-2… · the same entry in another collection · chain A against A, TM-score 1.00
- Q03526 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase ITK/TSK (Q03526) · a predicted model of the same protein · chain B against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q03526
- Elsewhere: RCSB PDB 2K79 · PDBe 2K79 · UniProt Q03526
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