MolNFT v1 · #41955 · protein

Haddock-derived structure of the ch-domain of the smoothelin-like 1 complexed with the C-domain of apocalmodulin

2K3S · Smoothelin-like protein 1: “Haddock-derived structure of the ch-domain of the smoothelin-like 1 complexed with the C-domain of…”. Solution nmr, 1 pocket (best druggability 0.26). MolNFT v1 #41955 on GenesisL1: 3D structure, binding…

PDB: 2K3S
Type: protein
Length: 186 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Smoothelin-like protein 1; Calmodulin
UniProt: Q99LM3, P62155
Pockets: 1 · best druggability 0.26

Structure

solution nmr · 2 distinct chains · 60% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Smoothelin-like protein 1	protein	119	61% helix, 0% strand	Q99LM3
B	Calmodulin	protein	67	58% helix, 6% strand	P62155

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	60	0.26	0.72	15	empty

Interfaces

1 interface between chains.

A–B · 795 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

2K3S · HADDOCK-derived structure of the CH-domain of the smoothelin-like 1 complexed with the… · the same entry in another collection · chain A against A, TM-score 1.00
Q99LM3 · AlphaFold monomer V2.0 prediction for smoothelin-like protein 1 (Q99LM3) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99LM3
Every structure of UniProt P62155
Elsewhere: RCSB PDB 2K3S · PDBe 2K3S · UniProt Q99LM3 · UniProt P62155

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