MolNFT v1 · #41931 · protein
Solution structure of cgmp-binding gaf domain of phosphodiesterase 5
2K31 · Phosphodiesterase 5A, cgmp-specific: “Solution structure of cgmp-binding gaf domain of phosphodiesterase 5”. Solution nmr, 1 ligand (35G), 2 pockets (best druggability 0.79). MolNFT v1 #41931 on GenesisL1: 3D structure, binding…
- PDB
- 2K31
- Type
- protein
- Length
- 149 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphodiesterase 5A, cgmp-specific
- EC
- 3.1.4.35
- UniProt
- Q0VBW0
- Ligands
- 35G
- Pockets
- 2 · best druggability 0.79
Structure
solution nmr · 1 distinct chain · 24% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphodiesterase 5A, cgmp-specific (EC 3.1.4.35) | protein | 149 | 24% helix, 30% strand | Q0VBW0 |
Ligands and binding sites
- 35G · Guanosine-3',5'-monophosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 178 | 0.79 | 0.93 | 29 | 35G |
| 2 | 130 | 0.49 | 0.78 | 23 | empty |
Compared structures
- 2K31 · Solution Structure of cGMP-binding GAF domain of Phosphodiesterase 5 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q0VBW0
- Elsewhere: RCSB PDB 2K31 · PDBe 2K31 · UniProt Q0VBW0
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