MolNFT v1 · #41894 · protein
R3/I5 relaxin chimera
2K1V · Relaxin-3: “R3/I5 relaxin chimera”. Solution nmr, 1 ligand (NH2). MolNFT v1 #41894 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2K1V
- Type
- protein
- Length
- 48 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Relaxin-3; Insulin-like peptide INSL5
- UniProt
- Q8WXF3, Q9Y5Q6
- Ligands
- NH2
Structure
solution nmr · 2 distinct chains · 44% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Relaxin-3 | protein | 27 | 44% helix, 4% strand | Q8WXF3 |
| A | Insulin-like peptide INSL5 | protein | 21 | 43% helix, 5% strand | Q9Y5Q6 |
Ligands and binding sites
- NH2 · Amino group · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- B–A · 748 Ų buried · 19 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide, 1 modified (disulfide, cyclization).
Compared structures
- 2K1V · R3/I5 relaxin chimera · the same entry in another collection · chain B against B, TM-score 1.00
- Q8WXF3 · AlphaFold monomer V2.0 prediction for relaxin-3 (Q8WXF3) · a predicted model of the same protein · chain B against A, TM-score 0.45
- Q9Y5Q6 · AlphaFold monomer V2.0 prediction for insulin-like peptide INSL5 (Q9Y5Q6) · a predicted model of the same protein · chain A against A, TM-score 0.34
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8WXF3
- Every structure of UniProt Q9Y5Q6
- Elsewhere: RCSB PDB 2K1V · PDBe 2K1V · UniProt Q8WXF3 · UniProt Q9Y5Q6
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