MolNFT v1 · #41878 · protein

NMR studies of a pathogenic mutant (D178N) of the human prion protein

2K1D · Major prion protein: “NMR studies of a pathogenic mutant (D178N) of the human prion protein”. Solution nmr, 1 pocket (best druggability 0.56). MolNFT v1 #41878 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2K1D
Type: protein
Length: 107 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Major prion protein
UniProt: P04156
Pockets: 1 · best druggability 0.56

Structure

solution nmr · 1 distinct chain · 57% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Major prion protein	protein	107	57% helix, 0% strand	P04156

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	226	0.56	0.78	26	empty

Compared structures

2K1D · NMR Studies of a Pathogenic Mutant (D178N) of the Human Prion Protein · the same entry in another collection · chain A against A, TM-score 1.00
P04156 · AlphaFold monomer V2.0 prediction for major prion protein (P04156) · a predicted model of the same protein · chain A against A, TM-score 0.67

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P04156
Elsewhere: RCSB PDB 2K1D · PDBe 2K1D · UniProt P04156

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