MolNFT v1 · #41529 · protein

VPS4A mit-CHMP1A complex

2JQ9 · Vacuolar protein sorting-associating protein 4A: “VPS4A mit-CHMP1A complex”. Solution nmr, 1 pocket (best druggability 0.29). MolNFT v1 #41529 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2JQ9
Type: protein
Length: 84 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Vacuolar protein sorting-associating protein 4A; Chromatin-modifying protein 1A
UniProt: Q9UN37, Q9HD42
Pockets: 1 · best druggability 0.29

Structure

solution nmr · 2 distinct chains · 87% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Vacuolar protein sorting-associating protein 4A	protein	71	87% helix, 0% strand	Q9UN37
B	Chromatin-modifying protein 1A	protein	13	85% helix, 0% strand	Q9HD42

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	56	0.29	0.74	13	empty

Interfaces

1 interface between chains.

A–B · 555 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

2JQ9 · VPS4A MIT-CHMP1A complex · the same entry in another collection · chain A against A, TM-score 1.00
Q9UN37 · AlphaFold monomer V2.0 prediction for vacuolar protein sorting- associated protein 4A… · a predicted model of the same protein · chain A against A, TM-score 0.90
Q9HD42 · AlphaFold monomer V2.0 prediction for charged multivesicular body protein 1A (Q9HD42) · a predicted model of the same protein · chain B against A, TM-score 0.70

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UN37
Every structure of UniProt Q9HD42
Elsewhere: RCSB PDB 2JQ9 · PDBe 2JQ9 · UniProt Q9UN37 · UniProt Q9HD42

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