MolNFT v1 · #41261 · protein

Human phosphoribosylpyrophosphate synthetase - associated protein 41 (PAP41)

2JI4 · Phosphoribosyl pyrophosphate synthetase-associated protein 2: “Human phosphoribosylpyrophosphate synthetase - associated protein 41 (PAP41)”. X-ray diffraction, 1 ligand (CL), 2 pockets (best druggability 0.46). MolNFT v1 #41261 on…

PDB: 2JI4
Type: protein
Length: 302 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phosphoribosyl pyrophosphate synthetase-associated protein 2
UniProt: O60256
Ligands: CL
Pockets: 2 · best druggability 0.46

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Phosphoribosyl pyrophosphate synthetase-associated protein 2	protein	302	37% helix, 24% strand	O60256

Ligands and binding sites

CL · Chloride ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	150	0.46	0.76	31	empty
2	145	0.44	0.76	25	CL

Compared structures

2JI4 · Human phosphoribosylpyrophosphate synthetase - associated protein 41 (PAP41) · the same entry in another collection · chain A against A, TM-score 1.00
O60256 · AlphaFold monomer V2.0 prediction for phosphoribosyl pyrophosphate synthase-associated… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O60256
Elsewhere: RCSB PDB 2JI4 · PDBe 2JI4 · UniProt O60256

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