MolNFT v1 · #41253 · protein
Crystal structure of rhogdi E155A, E157A mutant
2JHW · Rho GDP-dissociation inhibitor 1: “Crystal structure of rhogdi E155A, E157A mutant”. X-ray diffraction, 1 ligand (SO4), 4 pockets (best druggability 0.68). MolNFT v1 #41253 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 2JHW
- Type
- protein
- Length
- 276 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Rho GDP-dissociation inhibitor 1
- UniProt
- P52565
- Ligands
- SO4
- Pockets
- 4 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 4% helix, 56% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Rho GDP-dissociation inhibitor 1 | protein | 138 | 4% helix, 56% strand | P52565 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 5 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 71 | 0.68 | 0.94 | 26 | empty |
| 2 | 285 | 0.49 | 0.73 | 32 | empty |
| 3 | 107 | 0.47 | 0.79 | 20 | empty |
| 4 | 75 | 0.39 | 0.78 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 564 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52565
- Elsewhere: RCSB PDB 2JHW · PDBe 2JHW · UniProt P52565
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