MolNFT v1 · #41246 · protein

The structure of bluetongue virus VP4 reveals a multifunctional RNA- capping production-line

2JHP · VP4 core protein: “The structure of bluetongue virus VP4 reveals a multifunctional RNA- capping production-line”. X-ray diffraction, 2 ligands (SAH, GUN), 7 pockets (best druggability 0.70). MolNFT v1 #41246 on GenesisL1: 3D…

PDB: 2JHP
Type: protein
Length: 613 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: VP4 core protein
UniProt: P07132
Ligands: SAH, GUN
Pockets: 7 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	VP4 core protein	protein	613	34% helix, 16% strand	P07132

Ligands and binding sites

SAH · S-adenosyl-L-homocysteine · ligand · 2 copies · chains A
GUN · Guanine · ligand · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	82	0.70	0.95	28	empty
2	284	0.58	0.77	25	empty
3	277	0.57	0.77	30	empty
4	250	0.54	0.77	35	SAH, GUN
5	97	0.39	0.76	25	SAH

Compared structures

2JHP · The structure of bluetongue virus VP4 reveals a multifunctional RNA- capping… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07132
Elsewhere: RCSB PDB 2JHP · PDBe 2JHP · UniProt P07132

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