MolNFT v1 · #41233 · protein
The structure of bluetongue virus VP4 reveals a multifunctional RNA-capping production-line
2JHC · VP4 core protein: “The structure of bluetongue virus VP4 reveals a multifunctional RNA-capping production-line”. X-ray diffraction, 1 ligand (GUN), 7 pockets (best druggability 0.71). MolNFT v1 #41233 on GenesisL1: 3D structure…
- PDB
- 2JHC
- Type
- protein
- Length
- 613 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- VP4 core protein
- UniProt
- P07132
- Ligands
- GUN
- Pockets
- 7 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 33% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | VP4 core protein | protein | 613 | 33% helix, 17% strand | P07132 |
Ligands and binding sites
- GUN · Guanine · ligand · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 91 | 0.71 | 0.94 | 27 | empty |
| 2 | 281 | 0.57 | 0.77 | 36 | GUN |
| 3 | 265 | 0.56 | 0.77 | 25 | empty |
| 4 | 226 | 0.53 | 0.76 | 28 | empty |
| 5 | 122 | 0.42 | 0.76 | 15 | GUN |
Compared structures
- 2JHC · The structure of bluetongue virus VP4 reveals a multifunctional RNA- capping… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07132
- Elsewhere: RCSB PDB 2JHC · PDBe 2JHC · UniProt P07132
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