MolNFT v1 · #41121 · protein
The crystal structure of the tumor supressor protein PP32 ( ANP32A):STRUCTURAL insights into the ANP32 family of proteins
2JE1 · Acidic leucine-rich nuclear phosphoprotein 32 family member…: “The crystal structure of the tumor supressor protein PP32 ( ANP32A):STRUCTURAL insights into the ANP32 family…”. X-ray diffraction, 6 pockets (best druggability 0.55).…
- PDB
- 2JE1
- Type
- protein
- Length
- 596 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Acidic leucine-rich nuclear phosphoprotein 32 family member a
- UniProt
- P39687
- Pockets
- 6 · best druggability 0.55
Structure
x-ray diffraction · 1 distinct chain · 26% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Acidic leucine-rich nuclear phosphoprotein 32 family member a | protein | 149 | 26% helix, 15% strand | P39687 |
Ligands and binding sites
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 155 | 0.55 | 0.81 | 21 | empty |
| 2 | 139 | 0.49 | 0.79 | 18 | empty |
| 3 | 118 | 0.47 | 0.79 | 15 | empty |
| 4 | 149 | 0.46 | 0.76 | 27 | empty |
| 5 | 99 | 0.43 | 0.78 | 12 | empty |
Interfaces
3 interfaces between chains.
- C–D · 481 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 446 Ų buried · 8 hydrogen bonds · protein-protein
- A–D · 11 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2JE1 · The crystal Structure of the tumor supressor protein pp32 (Anp32a) :structural insights… · the same entry in another collection · chain D against D, TM-score 1.00
- P39687 · AlphaFold monomer V2.0 prediction for acidic leucine-rich nuclear phosphoprotein 32… · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P39687
- Elsewhere: RCSB PDB 2JE1 · PDBe 2JE1 · UniProt P39687
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