MolNFT v1 · #41120 · protein

Crystal structure of PP32

2JE0 · Acidic leucine-rich nuclear phosphoprotein 32 family member…: “Crystal structure of PP32”. X-ray diffraction, 12 pockets (best druggability 0.61). MolNFT v1 #41120 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2JE0
Type: protein
Length: 894 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Acidic leucine-rich nuclear phosphoprotein 32 family member a
UniProt: P39687
Pockets: 12 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 26% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F	Acidic leucine-rich nuclear phosphoprotein 32 family member a	protein	149	26% helix, 15% strand	P39687

Ligands and binding sites

GOL · Glycerol · additive · 11 copies · chains A, B, C, D, E, F

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	77	0.61	0.90	19	empty
2	236	0.59	0.80	29	empty
3	72	0.56	0.88	16	empty
4	186	0.50	0.77	31	empty
5	118	0.48	0.80	21	empty

Interfaces

7 interfaces between chains.

B–D · 444 Å² buried · 10 hydrogen bonds · protein-protein
C–E · 437 Å² buried · 10 hydrogen bonds · protein-protein
A–F · 433 Å² buried · 9 hydrogen bonds · protein-protein
C–F · 328 Å² buried · 1 hydrogen bond · protein-protein
E–F · 314 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

2JE0 · Crystal Structure of pp32 · the same entry in another collection · chain F against F, TM-score 1.00
P39687 · AlphaFold monomer V2.0 prediction for acidic leucine-rich nuclear phosphoprotein 32… · a predicted model of the same protein · chain C against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P39687
Elsewhere: RCSB PDB 2JE0 · PDBe 2JE0 · UniProt P39687

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