MolNFT v1 · #41090 · protein
Mouse laminin ALPHA1 chain, domains LG4-5
2JD4 · Laminin subunit alpha-1: “Mouse laminin ALPHA1 chain, domains LG4-5”. X-ray diffraction, 2 ligands (MG, CL), 5 pockets (best druggability 0.59). MolNFT v1 #41090 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2JD4
- Type
- protein
- Length
- 750 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Laminin subunit alpha-1
- UniProt
- P19137
- Ligands
- MG, CL
- Pockets
- 5 · best druggability 0.59
Structure
x-ray diffraction · 2 distinct chains · 1% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Laminin subunit alpha-1 | protein | 375 | 2% helix, 49% strand | P19137 |
| B | Laminin subunit alpha-1 | protein | 375 | 1% helix, 51% strand | P19137 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 230 | 0.59 | 0.80 | 36 | empty |
| 2 | 204 | 0.59 | 0.81 | 32 | empty |
| 3 | 252 | 0.55 | 0.77 | 35 | CL |
| 4 | 111 | 0.44 | 0.78 | 19 | empty |
| 5 | 61 | 0.30 | 0.75 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 454 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 2JD4 · Mouse laminin alpha1 chain, domains LG4-5 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19137
- Elsewhere: RCSB PDB 2JD4 · PDBe 2JD4 · UniProt P19137
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