MolNFT v1 · #41055 · protein
A viral protein unexpectedly mimics the structure and function of pro- survival BCL-2
2JBY · M11L protein: “A viral protein unexpectedly mimics the structure and function of pro- survival BCL-2”. X-ray diffraction, 1 ligand (NA), 1 pocket (best druggability 0.32). MolNFT v1 #41055 on GenesisL1: 3D structure, binding sites…
- PDB
- 2JBY
- Type
- protein
- Length
- 152 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- M11L protein; BCL-2 homologous ANTAGONIST/KILLER 2
- UniProt
- Q85295, Q13014
- Ligands
- NA
- Pockets
- 1 · best druggability 0.32
Structure
x-ray diffraction · 2 distinct chains · 72% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | M11L protein | protein | 127 | 72% helix, 0% strand | Q85295 |
| B | BCL-2 homologous ANTAGONIST/KILLER 2 | protein | 25 | 76% helix, 0% strand | Q13014 |
Ligands and binding sites
- NA · Sodium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 51 | 0.32 | 0.77 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 898 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 2JBY · A viral protein unexpectedly mimics the structure and function of pro- survival Bcl-2 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q85295
- Every structure of UniProt Q13014
- Elsewhere: RCSB PDB 2JBY · PDBe 2JBY · UniProt Q85295 · UniProt Q13014
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