MolNFT v1 · #40989 · protein
Structural insight into the escrt-I-II link and its role in mvb trafficking
2J9W · VPS28-prov protein: “Structural insight into the escrt-I-II link and its role in mvb trafficking”. X-ray diffraction, 2 pockets (best druggability 0.27). MolNFT v1 #40989 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2J9W
- Type
- protein
- Length
- 200 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- VPS28-prov protein
- UniProt
- Q7T0W4
- Pockets
- 2 · best druggability 0.27
Structure
x-ray diffraction · 2 distinct chains · 73% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | VPS28-prov protein | protein | 101 | 73% helix, 2% strand | Q7T0W4 |
| B | VPS28-prov protein | protein | 99 | 73% helix, 2% strand | Q7T0W4 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 58 | 0.27 | 0.73 | 15 | empty |
| 2 | 52 | 0.26 | 0.73 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 774 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 2J9W · Structural insight into the ESCRT-I-II link and its role in MVB trafficking · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7T0W4
- Elsewhere: RCSB PDB 2J9W · PDBe 2J9W · UniProt Q7T0W4
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