MolNFT v1 · #40892 · protein
Structural and functional characterisation of partner switching regulating the environmental stress response in bacillus subtilis
2J6Y · Phosphoserine phosphatase rsbu: “Structural and functional characterisation of partner switching regulating the environmental stress response…”. X-ray diffraction, 4 pockets (best druggability 0.56). MolNFT v1 #40892 on GenesisL1…
- PDB
- 2J6Y
- Type
- protein
- Length
- 416 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphoserine phosphatase rsbu
- EC
- 3.1.3.3
- UniProt
- P40399
- Pockets
- 4 · best druggability 0.56
Structure
x-ray diffraction · 5 distinct chains · 83% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphoserine phosphatase rsbu (EC 3.1.3.3) | protein | 85 | 84% helix, 0% strand | P40399 |
| B | Phosphoserine phosphatase rsbu (EC 3.1.3.3) | protein | 81 | 84% helix, 0% strand | P40399 |
| C | Phosphoserine phosphatase rsbu (EC 3.1.3.3) | protein | 85 | 79% helix, 0% strand | P40399 |
| D | Phosphoserine phosphatase rsbu (EC 3.1.3.3) | protein | 84 | 85% helix, 0% strand | P40399 |
| E | Phosphoserine phosphatase rsbu (EC 3.1.3.3) | protein | 81 | 84% helix, 0% strand | P40399 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 250 | 0.56 | 0.77 | 30 | empty |
| 2 | 286 | 0.52 | 0.74 | 29 | empty |
| 3 | 86 | 0.39 | 0.77 | 19 | empty |
| 4 | 66 | 0.33 | 0.76 | 14 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1816 Ų buried · 11 hydrogen bonds · protein-protein
- C–D · 1771 Ų buried · 11 hydrogen bonds · protein-protein
- A–C · 376 Ų buried · 5 hydrogen bonds · protein-protein
- B–E · 300 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 143 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 2J6Y · Structural and Functional Characterisation of partner switching regulating the… · the same entry in another collection · chain E against E, TM-score 1.00
- P40399 · AlphaFold monomer V2.0 prediction for phosphoserine phosphatase rsbu (P40399) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P40399
- Elsewhere: RCSB PDB 2J6Y · PDBe 2J6Y · UniProt P40399
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