MolNFT v1 · #40876 · protein

N-terminal SH3 domain of cms (CD2AP human homolog) bound to cbl-B peptide

2J6F · CD2-associated protein: “N-terminal SH3 domain of cms (CD2AP human homolog) bound to cbl-B peptide”. X-ray diffraction. MolNFT v1 #40876 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2J6F
Type: protein
Length: 65 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CD2-associated protein; E3 ubiquitin-protein ligase cbl-B
EC: 6.3.2.-
UniProt: Q9Y5K6, Q13191

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 43% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	CD2-associated protein	protein	57	5% helix, 49% strand	Q9Y5K6
C	E3 ubiquitin-protein ligase cbl-B (EC 6.3.2.-)	protein	8	0% helix, 0% strand	Q13191

Interfaces

1 interface between chains.

A–C · 502 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

2J6F · N-terminal SH3 domain of cms (CD2AP human homolog) bound to cbl-B peptide · the same entry in another collection · chain A against A, TM-score 1.00
Q9Y5K6 · AlphaFold monomer V2.0 prediction for CD2-associated protein (Q9Y5K6) · a predicted model of the same protein · chain A against A, TM-score 0.98
Q13191 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase cbl-B (Q13191) · a predicted model of the same protein · chain C against A, TM-score 0.55

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y5K6
Every structure of UniProt Q13191
Elsewhere: RCSB PDB 2J6F · PDBe 2J6F · UniProt Q9Y5K6 · UniProt Q13191

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