MolNFT v1 · #40868 · protein
The tir domain of human toll-like receptor 10 (TLR10)
2J67 · Toll like receptor 10: “The tir domain of human toll-like receptor 10 (TLR10)”. X-ray diffraction, 4 pockets (best druggability 0.67). MolNFT v1 #40868 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2J67
- Type
- protein
- Length
- 275 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Toll like receptor 10
- UniProt
- Q9BXR5
- Pockets
- 4 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Toll like receptor 10 | protein | 141 | 48% helix, 17% strand | Q9BXR5 |
| B | Toll like receptor 10 | protein | 134 | 47% helix, 18% strand | Q9BXR5 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 74 | 0.67 | 0.93 | 21 | empty |
| 2 | 218 | 0.58 | 0.79 | 27 | empty |
| 3 | 101 | 0.47 | 0.79 | 16 | empty |
| 4 | 50 | 0.25 | 0.73 | 11 | empty |
Interfaces
1 interface between chains.
- A–B · 762 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BXR5
- Elsewhere: RCSB PDB 2J67 · PDBe 2J67 · UniProt Q9BXR5
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