MolNFT v1 · #40606 · protein
Crystal structure of the PP2A phosphatase activator YPA2 PTPA2
2IXN · SERINE/THREONINE-protein phosphatase 2A activator 2: “Crystal structure of the PP2A phosphatase activator YPA2 PTPA2”. X-ray diffraction, 8 pockets (best druggability 0.64). MolNFT v1 #40606 on GenesisL1: 3D structure, binding sites…
- PDB
- 2IXN
- Type
- protein
- Length
- 578 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein phosphatase 2A activator 2
- UniProt
- Q12461
- Pockets
- 8 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 60% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein phosphatase 2A activator 2 | protein | 292 | 59% helix, 2% strand | Q12461 |
| B | SERINE/THREONINE-protein phosphatase 2A activator 2 | protein | 286 | 60% helix, 2% strand | Q12461 |
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 244 | 0.64 | 0.82 | 30 | empty |
| 2 | 304 | 0.62 | 0.79 | 43 | empty |
| 3 | 212 | 0.60 | 0.81 | 35 | empty |
| 4 | 107 | 0.51 | 0.82 | 18 | empty |
| 5 | 162 | 0.46 | 0.76 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 579 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 2IXN · CRYSTAL STRUCTURE OF THE PP2A PHOSPHATASE ACTIVATOR Ypa2 PTPA2 · the same entry in another collection · chain A against A, TM-score 1.00
- Q12461 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase 2A activator 2… · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12461
- Elsewhere: RCSB PDB 2IXN · PDBe 2IXN · UniProt Q12461
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