MolNFT v1 · #40465 · protein

NMR structure of haloferax volcanii DHFR

2ITH · Dihydrofolate reductase: “NMR structure of haloferax volcanii DHFR”. Solution nmr, 1 pocket (best druggability 0.61). MolNFT v1 #40465 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2ITH
Type: protein
Length: 162 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dihydrofolate reductase
EC: 1.5.1.3
UniProt: P15093
Pockets: 1 · best druggability 0.61

Structure

solution nmr · 1 distinct chain · 25% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Dihydrofolate reductase (EC 1.5.1.3)	protein	162	25% helix, 28% strand	P15093

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	57	0.61	0.92	16	empty

Compared structures

2ITH · NMR Structure of Haloferax volcanii DHFR · the same entry in another collection · chain A against A, TM-score 1.00
P15093 · AlphaFold monomer V2.0 prediction for dihydrofolate reductase hdra (P15093) · a predicted model of the same protein · chain A against A, TM-score 0.86

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P15093
Elsewhere: RCSB PDB 2ITH · PDBe 2ITH · UniProt P15093

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