MolNFT v1 · #40360 · protein

Structure of the pyocyanin biosynthetic protein phzm

2IP2 · Probable phenazine-specific methyltransferase: “Structure of the pyocyanin biosynthetic protein phzm”. X-ray diffraction, 8 pockets (best druggability 0.77). MolNFT v1 #40360 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 2IP2
Type: protein
Length: 660 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Probable phenazine-specific methyltransferase
EC: 2.1.1.-
UniProt: Q9HWH2
Pockets: 8 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 52% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Probable phenazine-specific methyltransferase (EC 2.1.1.-)	protein	330	52% helix, 16% strand	Q9HWH2

Pockets

8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	632	0.77	0.82	54	empty
2	715	0.77	0.81	62	empty
3	88	0.48	0.82	17	empty
4	147	0.44	0.76	24	empty
5	70	0.40	0.79	13	empty

Interfaces

1 interface between chains.

A–B · 3421 Å² buried · 44 hydrogen bonds · protein-protein

Compared structures

2IP2 · Structure of the Pyocyanin Biosynthetic Protein PhzM · the same entry in another collection · chain A against A, TM-score 1.00
Q9HWH2 · AlphaFold monomer V2.0 prediction for phenazine-1-carboxylate N-methyltransferase (Q9HWH2) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9HWH2
Elsewhere: RCSB PDB 2IP2 · PDBe 2IP2 · UniProt Q9HWH2

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