MolNFT v1 · #40332 · protein

Crystal structure of the cia- histone H3-H4 complex

2IO5 · ASF1A protein: “Crystal structure of the cia- histone H3-H4 complex”. X-ray diffraction, 3 pockets (best druggability 0.60). MolNFT v1 #40332 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2IO5
Type: protein
Length: 307 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ASF1A protein; Histone H3.1; Histone H4
UniProt: Q6IA08, P84233, P62799
Pockets: 3 · best druggability 0.60

Structure

x-ray diffraction · 3 distinct chains · 38% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ASF1A protein	protein	154	12% helix, 51% strand	Q6IA08
B	Histone H3.1	protein	76	71% helix, 4% strand	P84233
C	Histone H4	protein	77	57% helix, 8% strand	P62799

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	227	0.60	0.80	26	empty
2	137	0.44	0.76	24	empty
3	61	0.32	0.76	13	empty

Interfaces

3 interfaces between chains.

B–C · 2180 Å² buried · 14 hydrogen bonds · protein-protein
A–B · 951 Å² buried · 18 hydrogen bonds · protein-protein
A–C · 438 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

2IO5 · Crystal structure of the CIA- histone H3-H4 complex · the same entry in another collection · chain A against A, TM-score 1.00
P84233 · AlphaFold monomer V2.0 prediction for histone H3.2 (P84233) · a predicted model of the same protein · chain B against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6IA08
Every structure of UniProt P84233
Every structure of UniProt P62799
Elsewhere: RCSB PDB 2IO5 · PDBe 2IO5 · UniProt Q6IA08 · UniProt P84233 · UniProt P62799

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.