MolNFT v1 · #40297 · protein
The X-ray structure of a bak homodimer reveals an inhibitory zinc binding site
2IMT · Apoptosis regulator bak: “The X-ray structure of a bak homodimer reveals an inhibitory zinc binding site”. X-ray diffraction, 1 ligand (ZN), 1 pocket (best druggability 0.39). MolNFT v1 #40297 on GenesisL1: 3D structure, binding…
- PDB
- 2IMT
- Type
- protein
- Length
- 163 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Apoptosis regulator bak
- UniProt
- Q16611
- Ligands
- ZN
- Pockets
- 1 · best druggability 0.39
Structure
x-ray diffraction · 1 distinct chain · 75% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Apoptosis regulator bak | protein | 163 | 75% helix, 0% strand | Q16611 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 60 | 0.39 | 0.80 | 13 | empty |
Compared structures
- 2IMT · The X-ray Structure of a Bak Homodimer Reveals an Inhibitory Zinc Binding Site · the same entry in another collection · chain A against A, TM-score 1.00
- Q16611 · AlphaFold monomer V2.0 prediction for BCL-2 homologous ANTAGONIST/KILLER (Q16611) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q16611
- Elsewhere: RCSB PDB 2IMT · PDBe 2IMT · UniProt Q16611
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.