MolNFT v1 · #40091 · protein
Structure of an antibody-lysozyme complex: effect of a conservative mutation
2IFF · IGG1 hyhel-5 Fab (light chain): “Structure of an antibody-lysozyme complex: effect of a conservative mutation”. X-ray diffraction, 5 pockets (best druggability 0.49). MolNFT v1 #40091 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2IFF
- Type
- protein
- Length
- 555 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- IGG1 hyhel-5 Fab (light chain); IGG1 hyhel-5 Fab (heavy chain); Hen egg white lysozyme
- UniProt
- P00698
- Pockets
- 5 · best druggability 0.49
Structure
x-ray diffraction · 3 distinct chains · 15% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | IGG1 hyhel-5 Fab (light chain) | protein | 212 | 7% helix, 54% strand | — |
| H | IGG1 hyhel-5 Fab (heavy chain) | protein | 214 | 6% helix, 52% strand | — |
| Y | Hen egg white lysozyme | protein | 129 | 44% helix, 11% strand | P00698 |
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 277 | 0.49 | 0.73 | 49 | empty |
| 2 | 74 | 0.48 | 0.83 | 17 | empty |
| 3 | 100 | 0.39 | 0.76 | 17 | empty |
| 4 | 77 | 0.31 | 0.73 | 20 | empty |
| 5 | 58 | 0.29 | 0.75 | 14 | empty |
Interfaces
3 interfaces between chains.
- L–H · 1762 Ų buried · 17 hydrogen bonds · protein-protein
- H–Y · 513 Ų buried · 9 hydrogen bonds · protein-protein
- L–Y · 445 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 2IFF · Structure of an antibody-lysozyme complex: effect of a conservative mutation · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00698
- Elsewhere: RCSB PDB 2IFF · PDBe 2IFF · UniProt P00698
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