MolNFT v1 · #40085 · protein

Crystal structure of SV40 T-antigen origin binding domain disulfide- linked dimer

2IF9 · Large T antigen: “Crystal structure of SV40 T-antigen origin binding domain disulfide- linked dimer”. X-ray diffraction, 1 pocket (best druggability 0.26). MolNFT v1 #40085 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 2IF9
Type: protein
Length: 263 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Large T antigen
UniProt: P03070
Pockets: 1 · best druggability 0.26

Structure

x-ray diffraction · 2 distinct chains · 32% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Large T antigen	protein	132	31% helix, 33% strand	P03070
B	Large T antigen	protein	131	34% helix, 31% strand	P03070

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	53	0.26	0.73	13	empty

Interfaces

1 interface between chains.

A–B · 429 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

2IF9 · Crystal Structure of SV40 T-antigen origin binding domain disulfide-linked dimer · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03070
Elsewhere: RCSB PDB 2IF9 · PDBe 2IF9 · UniProt P03070

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