MolNFT v1 · #40041 · protein

Crystal structure of wheat C113S mutant EIF4E bound to 7-methyl-GDP

2IDV · Eukaryotic translation initiation factor 4E-1: “Crystal structure of wheat C113S mutant EIF4E bound to 7-methyl-GDP”. X-ray diffraction, 1 ligand (M7G), 1 pocket (best druggability 0.56). MolNFT v1 #40041 on GenesisL1: 3D structure…

PDB: 2IDV
Type: protein
Length: 177 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Eukaryotic translation initiation factor 4E-1
UniProt: P29557
Ligands: M7G
Pockets: 1 · best druggability 0.56

Structure

x-ray diffraction · 1 distinct chain · 28% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Eukaryotic translation initiation factor 4E-1	protein	177	28% helix, 30% strand	P29557

Ligands and binding sites

M7G · 7N-methyl-8-hydroguanosine-5'-diphosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	208	0.56	0.78	22	M7G

Compared structures

2IDV · Crystal structure of wheat C113S mutant EIF4E bound TO 7-methyl-GDP · the same entry in another collection · chain A against A, TM-score 1.00
P29557 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E-1… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P29557
Elsewhere: RCSB PDB 2IDV · PDBe 2IDV · UniProt P29557

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