Crystal structure of the ferripyoverdine receptor of the outer membrane of pseudomonas aeruginosa bound to ferripyoverdine.

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 55% strand (DSSP).

Ligands and binding sites

• PVE · (1S)-1-carboxy-5-[(3-carboxypropanoyl)amino]-8,9-dihydroxy-1,2,3,4-tetrahydropyrimido[1,2-a]quinolin-11-ium · ligand · chains A, I
• FE · Fe (III) ion · metal · chains A, I
• SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–I · 612 Ų buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 d-amino, 2 modified, 1 covalent, 1 isopeptide (D-amino acid, nonstandard, covalent ligand, isopeptide).

Compared structures

• 2IAH · Crystal structure of the ferripyoverdine receptor of the outer membrane of Pseudomonas… · the same entry in another collection · chain A against A, TM-score 1.00
• P48632 · AlphaFold monomer V2.0 prediction for ferripyoverdine receptor (P48632) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P48632
• Elsewhere: RCSB PDB 2IAH · PDBe 2IAH · UniProt P48632