MolNFT v1 · #39853 · protein

Crystal structure of human protein tyrosine phosphatase N4 (PTPN4)

2I75 · Tyrosine-protein phosphatase non-receptor type 4: “Crystal structure of human protein tyrosine phosphatase N4 (PTPN4)”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.47). MolNFT v1 #39853 on GenesisL1: 3D…

PDB: 2I75
Type: protein
Length: 273 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine-protein phosphatase non-receptor type 4
EC: 3.1.3.48
UniProt: P29074
Ligands: SO4
Pockets: 2 · best druggability 0.47

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48)	protein	273	34% helix, 23% strand	P29074

Ligands and binding sites

SO4 · Sulfate ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	151	0.47	0.77	21	SO4
2	50	0.31	0.76	13	empty

Compared structures

2I75 · Crystal Structure of Human Protein Tyrosine Phosphatase N4 (PTPN4) · the same entry in another collection · chain A against A, TM-score 1.00
P29074 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 4… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P29074
Elsewhere: RCSB PDB 2I75 · PDBe 2I75 · UniProt P29074

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