MolNFT v1 · #39846 · protein

Crystal structure of the multidrug efflux transporter acrb

2I6W · Acriflavine resistance protein B: “Crystal structure of the multidrug efflux transporter acrb”. X-ray diffraction, 10 pockets (best druggability 0.83). MolNFT v1 #39846 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2I6W
Type: protein
Length: 1,019 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Acriflavine resistance protein B
UniProt: P31224
Pockets: 10 · best druggability 0.83

Structure

x-ray diffraction · 1 distinct chain · 47% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Acriflavine resistance protein B	protein	1019	47% helix, 15% strand	P31224

Pockets

10 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1157	0.83	0.84	145	empty
2	96	0.49	0.81	33	empty
3	82	0.48	0.83	21	empty
4	128	0.40	0.74	19	empty
5	111	0.39	0.74	16	empty

Compared structures

2I6W · Crystal structure of the multidrug efflux transporter AcrB · the same entry in another collection · chain A against A, TM-score 1.00
P31224 · AlphaFold monomer V2.0 prediction for multidrug efflux pump subunit acrb (P31224) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P31224
Elsewhere: RCSB PDB 2I6W · PDBe 2I6W · UniProt P31224

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