MolNFT v1 · #39843 · protein
Orthorhombic structure of the ldh domain of human ubiquitin- conjugating enzyme E2-like isoform a
2I6T · Ubiquitin-conjugating enzyme E2-like isoform a: “Orthorhombic structure of the ldh domain of human ubiquitin- conjugating enzyme E2-like isoform a”. X-ray diffraction, 1 ligand (SO4), 9 pockets (best druggability 0.43). MolNFT v1…
- PDB
- 2I6T
- Type
- protein
- Length
- 562 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin-conjugating enzyme E2-like isoform a
- UniProt
- Q6P2F0
- Ligands
- SO4
- Pockets
- 9 · best druggability 0.43
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquitin-conjugating enzyme E2-like isoform a | protein | 280 | 45% helix, 21% strand | Q6P2F0 |
| B | Ubiquitin-conjugating enzyme E2-like isoform a | protein | 282 | 43% helix, 20% strand | Q6P2F0 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 133 | 0.43 | 0.76 | 23 | empty |
| 2 | 113 | 0.38 | 0.74 | 22 | empty |
| 3 | 53 | 0.36 | 0.79 | 16 | empty |
| 4 | 93 | 0.35 | 0.74 | 18 | empty |
| 5 | 75 | 0.31 | 0.73 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 1452 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 2I6T · Orthorhombic Structure of the LDH domain of Human Ubiquitin-conjugating Enzyme E2-like… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6P2F0
- Elsewhere: RCSB PDB 2I6T · PDBe 2I6T · UniProt Q6P2F0
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