MolNFT v1 · #39812 · protein
Crystal structure of hypothetical protein LOC79017 from homo sapiens
2I5T · Protein C7ORF24: “Crystal structure of hypothetical protein LOC79017 from homo sapiens”. X-ray diffraction, 8 pockets (best druggability 0.64). MolNFT v1 #39812 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2I5T
- Type
- protein
- Length
- 338 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein C7ORF24
- UniProt
- O75223
- Pockets
- 8 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein C7ORF24 | protein | 169 | 29% helix, 37% strand | O75223 |
| B | Protein C7ORF24 | protein | 169 | 30% helix, 37% strand | O75223 |
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 235 | 0.64 | 0.83 | 36 | empty |
| 2 | 195 | 0.64 | 0.84 | 34 | empty |
| 3 | 143 | 0.58 | 0.83 | 23 | empty |
| 4 | 161 | 0.56 | 0.81 | 23 | empty |
| 5 | 204 | 0.50 | 0.76 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 878 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 modified (engineered).
Compared structures
- 2I5T · Crystal Structure of hypothetical protein LOC79017 from Homo sapiens · the same entry in another collection · chain A against A, TM-score 1.00
- O75223 · AlphaFold monomer V2.0 prediction for gamma-glutamylcyclotransferase (O75223) · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75223
- Elsewhere: RCSB PDB 2I5T · PDBe 2I5T · UniProt O75223
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