MolNFT v1 · #39811 · protein + DNA

Crystal structure of onconase with bound nucleic acid

2I5S · P-30 protein: “Crystal structure of onconase with bound nucleic acid”. X-ray diffraction. MolNFT v1 #39811 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2I5S
Type: protein + DNA
Length: 106 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: P-30 protein; 5'-D(*A*(DU)P*GP*A)-3'
EC: 3.1.27.-
UniProt: P22069

Structure

x-ray diffraction · 2 distinct chains · 19% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
X	P-30 protein (EC 3.1.27.-)	protein	104	19% helix, 40% strand	P22069
A	5'-D(A(DU)PGPA)-3'	dna	2	—	—

Interfaces

1 interface between chains.

X–A · 392 Å² buried · 13 hydrogen bonds · protein-nucleic

Modifications

Observed in the structure: 4 disulfide, 1 modified (disulfide, cyclization).

Compared structures

2I5S · Crystal structure of onconase with bound nucleic acid · the same entry in another collection · chain X against X, TM-score 1.00
P22069 · AlphaFold monomer V2.0 prediction for protein P-30 (P22069) · a predicted model of the same protein · chain X against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22069
Elsewhere: RCSB PDB 2I5S · PDBe 2I5S · UniProt P22069

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