MolNFT v1 · #39615 · protein
Crystal structures of a poxviral glutaredoxin in the oxidized and reduced states show redox-correlated structural changes
2HZE · Glutaredoxin-1: “Crystal structures of a poxviral glutaredoxin in the oxidized and reduced states show redox-correlated…”. X-ray diffraction, 1 pocket (best druggability 0.59). MolNFT v1 #39615 on GenesisL1: 3D structure, binding…
- PDB
- 2HZE
- Type
- protein
- Length
- 219 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutaredoxin-1
- EC
- 1.8.5.1
- UniProt
- Q8JLF5
- Pockets
- 1 · best druggability 0.59
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutaredoxin-1 (EC 1.8.5.1) | protein | 110 | 43% helix, 18% strand | Q8JLF5 |
| B | Glutaredoxin-1 | protein | 109 | 43% helix, 18% strand | Q8JLF5 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 401 | 0.59 | 0.75 | 36 | empty |
Interfaces
1 interface between chains.
- A–B · 171 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 1 modified (artifact).
Compared structures
- 2HZE · Crystal structures of a poxviral glutaredoxin in the oxidized and reduced states show… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8JLF5
- Elsewhere: RCSB PDB 2HZE · PDBe 2HZE · UniProt Q8JLF5
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