MolNFT v1 · #39537 · protein
Fab fragment of humanized anti-viral antibody medi-493 (synagis tm)
2HWZ · Immunoglobulin Fab light chain: “Fab fragment of humanized anti-viral antibody medi-493 (synagis tm)”. X-ray diffraction, 3 pockets (best druggability 0.59). MolNFT v1 #39537 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 2HWZ
- Type
- protein
- Length
- 437 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Immunoglobulin Fab light chain; Immunoglobulin Fab heavy chain
- Pockets
- 3 · best druggability 0.59
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Immunoglobulin Fab light chain | protein | 210 | 6% helix, 51% strand | — |
| H | Immunoglobulin Fab heavy chain | protein | 227 | 8% helix, 52% strand | — |
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 72 | 0.59 | 0.90 | 22 | empty |
| 2 | 461 | 0.58 | 0.74 | 55 | empty |
| 3 | 204 | 0.54 | 0.78 | 30 | empty |
Interfaces
1 interface between chains.
- L–H · 1800 Ų buried · 19 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 2HWZ · Fab fragment of Humanized anti-viral antibody MEDI-493 (Synagis TM) · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2HWZ · PDBe 2HWZ
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