MolNFT v1 · #39511 · protein + RNA
Structure of ribosomal protein L1-mRNA complex at 2.1 resolution.
2HW8 · 36-mer: “Structure of ribosomal protein L1-mRNA complex at 2.1 resolution.”. X-ray diffraction, 2 ligands (MG, K), 1 pocket (best druggability 0.72). MolNFT v1 #39511 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2HW8
- Type
- protein + RNA
- Length
- 264 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 36-mer; 50S ribosomal protein L1
- UniProt
- P27150
- Ligands
- MG, K
- Pockets
- 1 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | 36-mer | rna | 36 | — | — |
| A | 50S ribosomal protein L1 | protein | 228 | 36% helix, 22% strand | P27150 |
Ligands and binding sites
- MG · Magnesium ion · metal · chains B
- K · Potassium ion · metal · chains B, A
- BU1 · 1,4-butanediol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1076 | 0.72 | 0.77 | 72 | MG |
Interfaces
1 interface between chains.
- B–A · 1218 Ų buried · 25 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 3 modified (engineered).
Compared structures
- 2HW8 · Structure of ribosomal protein L1-mRNA complex at 2.1 resolution. · the same entry in another collection · chain B against B, TM-score 1.00
- P27150 · AlphaFold monomer V2.0 prediction for 50S ribosomal protein L1 (P27150) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P27150
- Elsewhere: RCSB PDB 2HW8 · PDBe 2HW8 · UniProt P27150
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