MolNFT v1 · #39429 · protein

N8 neuraminidase in complex with zanamivir

2HTQ: “N8 neuraminidase in complex with zanamivir”. X-ray diffraction, 1 ligand (ZMR), 1 pocket (best druggability 0.62). MolNFT v1 #39429 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2HTQ
Type: protein
Length: 387 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Neuraminidase
EC: 3.2.1.18
UniProt: Q07599
Ligands: ZMR
Pockets: 1 · best druggability 0.62

Structure

x-ray diffraction · 1 distinct chain · 3% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Neuraminidase (EC 3.2.1.18)	protein	387	3% helix, 42% strand	Q07599

Ligands and binding sites

ZMR · Zanamivir · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	232	0.62	0.82	39	ZMR

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

2HTQ · N8 neuraminidase in complex with zanamivir · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q07599
Elsewhere: RCSB PDB 2HTQ · PDBe 2HTQ · UniProt Q07599

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.